Hyperoxia produces a significant increase in the amount of oxygen that is diluted in blood plasma, favoring cellular metabolism and allowing oxygen to reach the brain, cartilage, bones and tissue that due to diverse circulatory alterations do not properly receive it. This hyperoxia produces a large chain of physiological effects in the body.
The increase of available O2 in small arteries and capillaries promotes vasoconstriction, which occurs in healthy tissue without oxygen deterioration, promoting fluid redistribution of flow to hypoperfused zones.
Angiogenesis and Neovascularization
Hyperoxia stimulates and promotes the formation of small vessels promoting perfusion.
Stimulates collagen synthesis
Hyperoxia induces proline hydroxylation and fibroblast proliferation promoting collagen synthesis, critical to the wound healing process and tissue rehabilitation.
Stimulates cellular immunity
A type of white blood cell, the polymorphonuclears, use free radicals as a bactericidal mechanism. This process is favored and stimulated by the presence of O2.
Regulates Oxidative Stress and Inflammatory Response
Hyperoxia acts on regulators and mediators of the inflammatory response and decreases the oxidative stress resulting in anti-inflammatory effects and decreasing cellular damage.
Stem Cell Stimulation
Hyperoxia stimulates the differentiation and liberation of Stem Cells helping the tissue rehabilitation process and formation of new blood vessels.
Cellular immune response to infections
In adverse conditions such as hypoxia, it increases the susceptibility to infections and some immune cells respond to the presence of pathogenic noxae exerting its bactericidal action through ROS production, free radicals and peroxidase enzymes.
Hyperoxia stimulates the differentiation of bone-forming cells favoring osteogenesis and bone rehabilitation.
In addition to improving perfusion, through the formation of new vessels and cerebral oxygenation, hyperoxia increases neuroplasticity and stimulates peripheral axonal regeneration.
Increased success in flaps and implants
Hyperoxia increases the acceptance rate of implants and flaps used in burn and reconstructive surgery.